AraPerox

Peroxisome Biology of Plants and Microalgae

Research group by Prof. Dr. S. Reumann
Centre for Organelle Research (CORE)
University of Stavanger, Norway		 UiS logo

Microalgae

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 		Reumann lab > Group members 

Manish Budathoki
Manish
Manish Budathoki


Algae plate
Plate with microalgae


ABBB
Presentation at the ABBB 2013 conference in Toronto


Manish
Conference dinner at the CN Tower (Toronto, Canada)
Position PhD student
Nationality Nepalese
PhD project Comparative peroxisome analyses between higher plants and microalgae with focus on fatty acid metabolism
Animal, plant and microalgal cells are subdivided into compartments. In addition to mitochondria, plastids and the cell nucleus, peroxisomes are essential cell organelles, in which many important metabolic reactions take place such as fatty acid catabolism. Microalgae attract increasing biotechnological interest due to their high biomass productivity including oils and omega-3 fatty acids. These are very important ingredients as fish feed to Norwegian aquaculture. The major objective of his PhD project is to predict and experimental validate the proteome of microalgal peroxisomes and compare it to that of higher plants using the model plant Arabidopsis thaliana. Prediction models are being developed for PTS2 proteins in collaboration with Dr. T. Lingner (University of Goettingen, Germany) and experimentally validated. Nuclear transformation and gene knock-out technology by homologous recombination are being etstablished in the group and shall be applied to optimize metabolic pathway optimization and increase the oil and PUFA levels in microalgae. 
Funding Ministry for Research and Education Norway
Publications Lamichhane J., Karki T., Nepal A., Budathoki M., and Sharma A.K. (2012) Production and optimization of ethanol from cheese whey by constitutive use of Saccharomyces cerevisiae and Kluyveromyces lactis NCYC752. J. Biomolecule Reconstruction 9: 1-7
Education
2010-2012
 Master’s degree in Biological Chemistry (University of Stavanger, Norway), thesis title: “Identification of predicted novel plant peroxisomal targeting signal 2 (PTS2) by in vivo subcellular targeting analyses and further development of a relational database for Arabidopsis peroxisome proteins”; supervisor: Prof. Dr. Sigrun Reumann
2004-2009
 B. Tech. in Biotechnology (Kathmandu University, Dhulikhel, Nepal)
     
Research interests Cell signaling, molecular evolution, cell and molecular biology, organization and function of the eukaryotic genomes, optimization of lipid metabolism in eukaryotes
Research expertise Bioinformatics, Molecular biology, Microscopy, Proteomics
Contact Manish Budathoki
Centre for Organelle Research (CORE)
University of Stavanger
Richard Johnsonsgate 4
N-4021 Stavanger, Norway
Phone:  +47-51831817 (Laboratory)
Email: manish.budathoki[at]uis.no
Homepage: http://core.uis.no; www.ux.uis.no/reumann


Manish
Celebration of the BIOTEK 2021
Microalgae grant


 Manish_7
Poster preparation for the PERFUME Kick-off conference
in Groningen (The Netherlands)
ManishMara
Challenging lab work